Possibilities of using micronucleus analysis to detect gene mutations in animals

Relevance. The main purpose of micronuclear analysis is to identify substances that cause cytotoxic damage and lead the formation micronuclei containing lagging fragments chromosomes or whole chromosomes. For study chromosomal disorders, now very often used, since it quite easy perform does not require large costs. Methods results. Micronuclei are cytoplasmic chromatin-containing bodies formed when delayed in anaphase telophase during cell division fragmentation nucleus apoptosis. method used as a biomarker aberrations mutagenicity, well marker development oncological diseases. With quantitative changes DNA cell, occurs. It their presence an indicator body was exposed environmental pollution (pesticides, pesticides, radiation, heavy metals, etc.), leading inflammatory pathological processes. Recently, many studies have been conducted aimed at studying influence factors on genetic apparatus body. Under mutagens, proliferating cells, counting which allows for diagnosis both genotoxic stress instability organism. To determine early humans animals, sensitive labor-intensive methods needed, can be attributed analysis. has become relevant its use livestock sector, mainly research quality control products future human nutrition.